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Ex-USMLE Forums Staff
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Discussion Starter #1
Pure As Gold
Purines Adenine and Guanine

Pyrimidine = CUT
Cytosine, Uracil, Thymine

The sequence of these is important as when you de-aminate Adenine you'll get Guanine and when you de-aminate Cytosine you'll get Uracil which by methylation can become Thymine.

U to T methylation is done by Thymidilate synthase which is blocked by 5FU
A to G deamination is done by adenosine deaminase which is deficient in Severe Combined Immunodeficiency
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