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Hi guys, I know, C1 esterase inhibitor deficiency causes hereditary angioedema but I am curious to know function of C1 esterase.I googled but didn't find, can anybody help.Thanks.
 

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Hi there,

Predictably, C1 esterase (C1-inh) is an inhibitor of the complement system. However, it also has an inhibitory effect on kallikrein. In hereditary angioedema, C1-inh deficiency results in upregulation of kallikrein and thus increased production of bradykinin, which as one of the most potent vasodilators, leads to vascular leakage and angioedema.

Hope this helps.
 

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C1 esterase converts C1 into C2C3 and activate the pathway ... C1 esterase inhibitor is a factor which inhibits C1 esterase so immature activation doesn't occur ... Simple as that
 

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therealdeal is right, although I was talking about C1 esterase inhibitor (C1-inh), I accidentally wrote ''C1 esterase'' instead. I think you can tell, though.
 
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