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Discussion Starter · #1 ·
A healthy 19-year-old man receives a tetanus immunization booster prior to induction into the US Marines. Six hours later, he has pain and massive swelling at the site of injection. The following day, the skin breaks down, forming an ulcer at the site. Which of the following events plays a critical role in this reaction?

(A) Accumulation of mononuclear cells atthe site of antigen injection
(B) Antigen capture by Langerhans cells inthe epidermis
(C) Local fixation of complement bypreformed circulating antibodies
(D) Local release of histamine
(E) Predominant synthesis of IgMantibodies
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