[lee-usmle]

Often tested in USMLE and perhaps more than the disease!

Classic clues in the case are:

• African American
• Developed dyspnea in Denver (high altitude)
• Sudden death after sustained prolonged exercise
• Rhabdomyolyis and red urine
• Renal papillary necrosis and sloughing
• Heterozygote Hemoglobin electrophoresis blot