A 61-year-old woman develops a severe skin disease characterized by multiple oral ulcers and flaccid bullae that rupture easily on her scalp, face, and trunk with Positive Nikolsky sign. Autoimmune attack on which of the following structures is thought to contribute to the pathophysiology of this disease?
(A) Actin microfilaments
(B) Desmosomes
(C) Gap junctions
(D) Microtubules
(E) Tight junctions
(A) Actin microfilaments
(B) Desmosomes
(C) Gap junctions
(D) Microtubules
(E) Tight junctions