Some Confusing Questions about Nitropresside and Framshift mutations

Haisook said:

[*]In frameshift mutation, there's deletion of a number not divisible by 3 of bases or nucleotides?
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Thanks in advance.
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I'll just answer this 1 first b/c it will take the least amount of time

Frameshift mutation = nucleotide addition or deletion, when they say not divisible by 3, they just mean that the whole picture moves, if you add or delete 3 then you delete 1 whole gene codon, it wouldn't mess up the rest of the sequence because the rest of those proteins will still be accounted for, however if you add or delete 1 or 2 nucleotides....then you change the whole frame....for example.

AAA BBB CCC
when you add or delete 1 or 2 nucleotides, you will have (in this case delete)
AAA BBC CC

now the BBB and BBC per say will not code for the same protein....etc, etc

nucleotide = Base + Sugar + PO4
Base = just the Nucleobase i.e A, T, C, G, U

Haisook said:

I figured out point 1.

Nitrites can cause methemoglobinemia by oxidation of Fe2+ to Fe3+. MetHb is treated with methylene blue.

Surprisingly, this toxicity can also be used as a treatment in cyanide poisoning. MetHb loves CN more than oxygen. So, providing MetHb in CN poisoning will lead to formation of MetHb-CN complexes. At this point, Na thiosulfate is given to bind these complexes and excrete them in the kidneys.

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hmmm, maybe I just didn't understand ur question right! but yeah all of this is mentioned in Goljan