Drug Y has a volume of distribution (Vd) of 75 L in both younger and older adult men. In younger adults, it has a clearance rate of 15L/h, 50% of which is via the liver and 50% via the kidneys. For younger men, the maintenance regimen is 100 mg every 6 hours. Which of the following regimens will produce essentially the same steady-state concentration in an older man, whose creatinine clearance is half that of younger men, but whose hepatic function is unimpaired?
A. 75 mg every 3 hours
B. 75 mg every 6 hours
C. 75 mg every 9 hours
D. 100 mg every 3 hours
E. 100 mg every 6 hours
F. 100 mg every 12 hours
A. 75 mg every 3 hours
B. 75 mg every 6 hours
C. 75 mg every 9 hours
D. 100 mg every 3 hours
E. 100 mg every 6 hours
F. 100 mg every 12 hours