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Discussion Starter #1
Q NO 209: A 60-year-old male is treated with losartan for hypertension. His blood pressure decreases to normal value over several weeks of treatment. He seems to be compliant with his medication and experiences no significant side effects. Which of the following is the most likely combination of changes in response to this patients treatment?


Renin Angiotensin I Angiotensin II Aldosterone Bradykinin
A. Increase Increase Decrease Decrease Increase
B. Increase Increase Increase Decrease Increase
C. Increase Increase Increase Decrease No change
D. Increase Increase Decrease Decrease Decrease
E. Increase Decrease Decrease Decrease Decrease
F. Decrease Decrease Decrease Decrease No change
 

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Q NO 209: A 60-year-old male is treated with losartan for hypertension. His blood pressure decreases to normal value over several weeks of treatment. He seems to be compliant with his medication and experiences no significant side effects. Which of the following is the most likely combination of changes in response to this patients treatment?

Renin Angiotensin I Angiotensin II Aldosterone Bradykinin
A. Increase Increase Decrease Decrease Increase
B. Increase Increase Increase Decrease Increase
C. Increase Increase Increase Decrease No change
D. Increase Increase Decrease Decrease Decrease
E. Increase Decrease Decrease Decrease Decrease
F. Decrease Decrease Decrease Decrease No change
the correct answer is c
because losartan is angiotensinII receptor blocker
 

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Discussion Starter #4
ARBs work by blocking AT-II receptors. This results in arterial vasodilation and decreased aldosterone secretion.

Since ARBs work at the level of AT-II receptors and do not affect ACE activity. They do not interfere with bradykinin degradation or levels. By blocking AT-II receptors, AREs also interfere with negative feedback mechanisms resulting in increased renin, angiotensin I, and angiotensin II levels.
 
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