Hello forum members,
Just thought I would share these HY notes with you all.
Good Luck!
Just thought I would share these HY notes with you all.
Good Luck!
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ARE you sure about thyroid and vitD receptors being inside nucleus? are not they in cytoplasm? just wondering! different sources different inputsHello forum members,
Just thought I would share these HY notes with you all.
Good Luck!
ok i just read that thyroid hormones receptors are located in nucleus but still not sure about vit.D.ARE you sure about thyroid and vitD receptors being inside nucleus? are not they in cytoplasm? just wondering! different sources different inputs
Vitamin D is fat soluble and therefore it must be able to slip through the cell membrane and nuclear membrane and exerts its action there.ok i just read that thyroid hormones receptors are located in nucleus but still not sure about vit.D.
ANYONE? ANY IDEAS?
Not necessary. we are talking about whether receptor is in cytoplasm or in nucleus. as you know steroid hormones -glucocorticoids, testosteron,..-are all lipid soluble but their receptor are located in cytoplasm. please correct me if i am missing something here.Vitamin D is fat soluble and therefore it must be able to slip through the cell membrane and nuclear membrane and exerts its action there.
Steroid hormone receptors are located in the nucleus not in the cytoplasm.Not necessary. we are talking about whether receptor is in cytoplasm or in nucleus. as you know steroid hormones -glucocorticoids, testosteron,..-are all lipid soluble but their receptor are located in cytoplasm. please correct me if i am missing something here.
you can not always trust wikipedia..Steroid hormone receptors are located in the nucleus not in the cytoplasm.
When a substance is lipid soluble, there's no need for cell surface or cytoplasmic receptor as it can diffuse in.
To reaffirm for you the location of Vitamin D receptor please read this Wikipedia article http://en.wikipedia.org/wiki/Calcitriol_receptor
What you said, means that the ultimate receptor for steroids is in the nucleus!I am pretty sure steroid receptors are in cytoplasmn when hormone binds receptor then H-R complex is dislocated into nucleus and seat on HRE.
that is why i asked about vitD, different sources different info..The attached pdf states
nuclear receptor for T3/T4 & VitA & Vit D
but FA 2011 states Vit D as cytosolic
can anyone tell which one is correct? :toosad: