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A 67-year-old male is brought to the emergency department with complaints of crushing substernal chest pressure. An electrocardiogram reveals changes consistent with an anterolateral myocardial infarction. He is administered streptokinase. Which of the following best describes the thrombolytic action of streptokinase?

A. Activation of antithrombin III
B. Activation of circulating plasminogen
C. Activation of plasminogen bound to fibrin
D. Cleavage of fibrinogen to fibrin
E. Competitive inhibition of fibrin degradation
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