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Teen with Liver Problem + Personality Changes

12357 Views 2 Replies 3 Participants Last post by  dr_pawandeep
If the question stem describes a child with signs of chronic liver disease such as bleeding tendency, signs of liver cirrhosis, jaundice, elevated LFTs, ...etc.
Plus a noticeable change in behavior such as clumsiness or even some Parkinsonian symptoms.

Think Wilson's Disease immediately.

They may also show you this picture (click the thumbnail to enlarge)

Brown Head Eye Eyelash Human body

This picture is copied from Wikimedia page

In addition to the Kayser Fleischer ring shown above,
The question may ask about the mode of inheritance (autosomal recessive) or treatment (Pencillamine or liver transplantation) or lab abnormalities (decreased ceruloplasmin and increased urinary copper) and the gold standard for the diagnosis is Liver Biopsy.
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Hi, Ceruloplasmin level is increased.
low ceruloplasmin level is not diagnostic for Wilson's disease in the absence of Kayser-Fleischer rings
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