A 14-year-old female complains to her pediatrician of fatigue and occasional yellowish discoloration to her skin. She has marked splenomegaly. Laboratory studies are obtained, leukocytes 3.4 / mm3, hematocrit 30%, hemoglobin 9.6 g/dL, MCV 90 fL, MCHC 45%, platelets 250,000 / uL. Peripheral smear demonstrates spherocytes. Which of the following abnormal proteins is most likely the cause of this patient’s signs and symptoms?
A- a - globin
B- Ankyrin
C- ß - globin
D- Protein 4.2
E- Spectrin
A- a - globin
B- Ankyrin
C- ß - globin
D- Protein 4.2
E- Spectrin