[hana]

What is the cause of enlarged thyroid gland in Hashimoto thyroiditis ? is it due to inflammatory cells infiltration or is it b/c of TSH?

Can TSH work on thyroid gland at all? is not there antibody against TSH receptors ?

Thanks

 

[dr z]

hashimoto and goiter

goljan says​

Pathogenesis of Hashimoto's thyroiditis
(1) Cytotoxic T cells destroy parenchyma (type IV hypersensitivity).
• Initial thyrotoxicosis, eventual hypothyroidism
(2) Blocking IgG autoantibodies against che TSH receptor
• Decrease hormone synthesis; type II hypersensitivicy
(3) Antimicrosomal and thyroglobulin antibodies​

• Develop as a result of gland injury; no causal role

Gross and microscopic features of Hashimoto's thyroiditis
(1) Enlarged, gray gland​

(2) Lymphocytic infiltrate with prominent germinal follicles

(i think this is the cause of slowly increasing galnd size)

 

[hana]

so drZ "(i think this is the cause of slowly increasing galnd size) " you think this is the cause of goiter in hashimoto ,right? TSH can not work on thyroid gland-b/c of IGs againts its receptor,is that what you mean?
any other ideas other fellows?

 

[dr z]

....

Yes , coz the lymphocytic infiltration with prominent germinal centers of the thyroid galnd increase its size over a period of time