A.
Just guess. More rational.
Just guess. More rational.
The cause of this jaundice
A 19-year-old male presents to the student health service after his roommate noted a yellowish discoloration to his skin while up late studying for an exam. After a meal and several hours sleep, the discoloration resolved. Laboratory tests are obtained, ALT 25 U/dL, AST 20 U/dL, Bilirubin (direct) 0.8 mg/dL, Bilirubin (total) 2.5 mg/dL. Which of the following is responsible for this patient’s disease?
A- Canalicular cholestasis
B- Decreased activity of glucuronyl transferase
C- Impaired transport of bilirubin into the bile canaliculus
D- Impaired uptake of circulating bilirubin
E- Immune hemolysis
A- Canalicular cholestasis
B- Decreased activity of glucuronyl transferase
C- Impaired transport of bilirubin into the bile canaliculus
D- Impaired uptake of circulating bilirubin
E- Immune hemolysis
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This is typical presentation of Gilbert's syndrome (very impressive name, though harmless!), aka glycuronyl-transferase deficiency/insufficiency. The scenario describes a teenager/young adult with manifestation of jaundice after stress and low food intake. There are no pathophysiologic sequelae for this entity and the prognosis is excellent.
Binding of indirect bilirubin to glycuronic acid is the first step of rendering bilirubin water soluble (i.e. direct) and thus excretable (through the GI tract and the urine). Consequently, these patients manifest INdirect hyperbilirubinemia.
Binding of indirect bilirubin to glycuronic acid is the first step of rendering bilirubin water soluble (i.e. direct) and thus excretable (through the GI tract and the urine). Consequently, these patients manifest INdirect hyperbilirubinemia.
Thanks
Mild jaundice (harmless) may appear under conditions of exertion, stress, fasting, and infections.
You are right. It's Gilbert's syndrome.This is typical presentation of Gilbert's syndrome (very impressive name, though harmless!), aka glycuronyl-transferase deficiency/insufficiency. The scenario describes a teenager/young adult with manifestation of jaundice after stress and low food intake. There are no pathophysiologic sequelae for this entity and the prognosis is excellent.
Binding of indirect bilirubin to glycuronic acid is the first step of rendering bilirubin water soluble (i.e. direct) and thus excretable (through the GI tract and the urine). Consequently, these patients manifest INdirect hyperbilirubinemia.
Mild jaundice (harmless) may appear under conditions of exertion, stress, fasting, and infections.
This is Gilbert's syndrome. This has both problems in which Answer choices are B and D. I will shoot for D. Which one do you go for?A 19-year-old male presents to the student health service after his roommate noted a yellowish discoloration to his skin while up late studying for an exam. After a meal and several hours sleep, the discoloration resolved. Laboratory tests are obtained, ALT 25 U/dL, AST 20 U/dL, Bilirubin (direct) 0.8 mg/dL, Bilirubin (total) 2.5 mg/dL. Which of the following is responsible for this patient's disease?
A- Canalicular cholestasis
B- Decreased activity of glucuronyl transferase
C- Impaired transport of bilirubin into the bile canaliculus
D- Impaired uptake of circulating bilirubin
E- Immune hemolysis
Dr. Ali u are right that this is Gilbert syndrome and both A and D are right but what will I choose?This is Gilbert's syndrome. This has both problems in which Answer choices are B and D. I will shoot for D. Which one do you go for?
I will choose A. My reasons are not conviencing though.
1 - 6 of 6 Posts
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