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can anyone explain please the role of beta microglobulin in MHC CLASS 1, antigen processing? :toosad:
 

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β2 microglobulin is necessary for cell surface expression of MHC class I and stability of the peptide binding groove.
in deficiency of it u may hv less expression of MHC class 1 molecule or less functioning MHC class 1 molecule on all nucleated cells...
i dont think we hv to know this in much detail....:indifferent:
 

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what would the deficiency of alpha 2 microglobulin cause?
am autoimmune or an immunodeficiency disease?
 
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