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The zygote chromosome in the case of a complete hydatiform mole is product of;
1- empty ovum fertilization by 2 sperms OR
2- empty ovum fertilized by 1 sperm which its DNA is duplicated later on?

Thanks
Complete Moles:
  • 80% are 1 sperm which is duplicated (homozygote, uniparental, unispermy, always 46XX)
  • 20% are 2 sperms (heterozygote, uniparental, dispermy, could be 46XX or 46XY)

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@mondoshawan;
what is your refrence for this "20% are 2 sperms (heterozygote, uniparental, dispermy, could be 46XX or 46XY" cause i had this thought that complete mole is only 46xx.
thanks
Hydatidiform Mole: eMedicine Obstetrics and Gynecology

They also say that 90% are XX and 10% are XY - which makes sense, if all 80% that are homozygous are XX and half of the 20% that are heterozygous are XX.

DynaMed also cites the 90%/10% for XX/XY

hope that helps!
 
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