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Discussion Starter #1
Hello,

Transposition of the great arteries
failure of migration of NCC or failure of spiralization?

It seems they are not consistent?

Thanks for the help!
 

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Failure of spiralization. Its basically the spiral orientation of the aorticopulmonary septum which causes the aorta to arise from the left ventricle even though it is anatomically located to the right of the pulmonary trunk.
 

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Failure of spiralization. Its basically the spiral orientation of the aorticopulmonary septum which causes the aorta to arise from the left ventricle even though it is anatomically located to the right of the pulmonary trunk.
FA 2016, p.263:
Conotruncal abnormalities associated with
failure of neural crest cells to migrate:
ƒ Transposition of great vessels.
ƒ Tetralogy of Fallot.
ƒ Persistent truncus arteriosus.

I saw a question that had both answers,
failure of spiralization and failure of migration.
 

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FA 2016, p.263:
Conotruncal abnormalities associated with
failure of neural crest cells to migrate:
ƒ Transposition of great vessels.
ƒ Tetralogy of Fallot.
ƒ Persistent truncus arteriosus.

I saw a question that had both answers,
failure of spiralization and failure of migration.
I assume, you're talking about a UWorld question. And what was the correct answer to that question?

For any Step 1 question, choose the option which makes sense to you, based on your understanding of Embryology. The exam is a test of your understanding and application of basic principles to clinical scenarios, not how well you memorized FA.
 
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