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A pregnant female did ultrasound and it was reported as the baby is having a fluid sac on the lower back. What medication could exacerbate the dietary deficiency responsible for the this defect?

a- Carbamazepine
b- Co trimaxazole
c- Lithium
d- Valproic Acid
e- Captopril

Ok guys let's see who'll get the question right :rolleyes:
 

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A pregnant female did ultrasound and it was reported as the baby is having a fluid sac on the lower back. What medication could exacerbate the dietary deficiency responsible for the this defect?

a- Carbamazepine
b- Co trimaxazole
c- Lithium
d- Valproic Acid
e- Captopril

Ok guys let's see who'll get the question right :rolleyes:
I think it is NTD caused by folate deficiency..
From interfering the dietary folate absorption and associated with NTD , most likely the drug will be anticonvulsant...
So i chose valproic acid as it is a teratogenic anticonvulsant causing NTD
 

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Discussion Starter #3
I think it is NTD caused by folate deficiency..
From interfering the dietary folate absorption and associated with NTD , most likely the drug will be anticonvulsant...
So i chose valproic acid as it is a teratogenic anticonvulsant causing NTD
Correct!

How did you know that!

Why not co trimaxazole, isn't it anti folate?
Why not carbmazepine, it also causes spina bifida?
 

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Correct!

How did you know that!

Why not co trimaxazole, isn't it anti folate?
Why not carbmazepine, it also causes spina bifida?
For cotrimazole. it inhibits folate syn: in bacteria and not in human ...
for carbamazepine, it stays 2nd compared to valproic acid although there is association with NTD.
 
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