[khanar]

A pregnant female did ultrasound and it was reported as the baby is having a fluid sac on the lower back. What medication could exacerbate the dietary deficiency responsible for the this defect?

a- Carbamazepine
b- Co trimaxazole
c- Lithium
d- Valproic Acid
e- Captopril

Ok guys let's see who'll get the question right

 

[smile135]

A pregnant female did ultrasound and it was reported as the baby is having a fluid sac on the lower back. What medication could exacerbate the dietary deficiency responsible for the this defect?

a- Carbamazepine
b- Co trimaxazole
c- Lithium
d- Valproic Acid
e- Captopril

Ok guys let's see who'll get the question right

I think it is NTD caused by folate deficiency..
From interfering the dietary folate absorption and associated with NTD , most likely the drug will be anticonvulsant...
So i chose valproic acid as it is a teratogenic anticonvulsant causing NTD

 

[khanar]

I think it is NTD caused by folate deficiency..
From interfering the dietary folate absorption and associated with NTD , most likely the drug will be anticonvulsant...
So i chose valproic acid as it is a teratogenic anticonvulsant causing NTD

Correct!

How did you know that!

Why not co trimaxazole, isn't it anti folate?
Why not carbmazepine, it also causes spina bifida?

 

[khanar]

Why not co trimaxazole, isn't it anti folate?

Sulfonamides inhibit folate synthesis in bacteria not humans
human do not make folate

 

[smile135]

Correct!

How did you know that!

Why not co trimaxazole, isn't it anti folate?
Why not carbmazepine, it also causes spina bifida?

For cotrimazole. it inhibits folate syn: in bacteria and not in human ...
for carbamazepine, it stays 2nd compared to valproic acid although there is association with NTD.

 

[afridi123]

valpraoic acid and phenytoin inhibit the intestinal conjugases which are responisble for folic acid absorption