Tumor Suppressor Genes Mnemonic
Yah, I agree with you this is one of the most difficult tables to grasp and memorize
However, this might help you
As for the names, fortunately, they all adequately represent the diseases they cause (except perhaps for the most important one of them which is P53).
So for example VHL is simply von Hippel-Lindau, WT is Wilm's Tumor, Rb is Retinoblastoma, BRCA is breast Cancer, NF is for Neurofibromatosis, APC is for adenomatous polyposis coli, DCC stands for Deleted in Colon Cancer, DPC stands for Deleted in Pancreatic Cancer.
Now what's really difficult to remember (and often asked in USMLE) is the chromosomal locations of these genes.
this might help
Just remember that all the numbers are odd except for chromosome 18 in the case of DCC/DPC
The rest are:
3, 5, 9, 11, 13, 17 for these numbers remember
Very Peculiar Formula With Rusting P53
V = von Hippel-Lindau (three names and chromosome three)
P = Polyps as APC is in chr 5
Fm = Familial melanoma is in chromosome 9
W = Wilm's in chr 11
R = Rb in chr 13
P53 = in chromosome 17 and particularly the short arm
Yah, I agree with you this is one of the most difficult tables to grasp and memorize
However, this might help you
As for the names, fortunately, they all adequately represent the diseases they cause (except perhaps for the most important one of them which is P53).
So for example VHL is simply von Hippel-Lindau, WT is Wilm's Tumor, Rb is Retinoblastoma, BRCA is breast Cancer, NF is for Neurofibromatosis, APC is for adenomatous polyposis coli, DCC stands for Deleted in Colon Cancer, DPC stands for Deleted in Pancreatic Cancer.
Now what's really difficult to remember (and often asked in USMLE) is the chromosomal locations of these genes.
this might help
Just remember that all the numbers are odd except for chromosome 18 in the case of DCC/DPC
The rest are:
3, 5, 9, 11, 13, 17 for these numbers remember
Very Peculiar Formula With Rusting P53
V = von Hippel-Lindau (three names and chromosome three)
P = Polyps as APC is in chr 5
Fm = Familial melanoma is in chromosome 9
W = Wilm's in chr 11
R = Rb in chr 13
P53 = in chromosome 17 and particularly the short arm
