USMLE Forums banner

1 - 4 of 4 Posts

·
Registered
Joined
·
67 Posts
Discussion Starter #1
can someone please explain this question
i dont understand what does the sibling and patient having 126 bp and 124bp mean ?

Qid:1412 biochemistry frameshit mutation in a patient with cystic fibrosis
 

·
Registered
Joined
·
8 Posts
Codon deletion is deletion of 3 base pairs or bp with in multiples of 3 eg 6bp, 9bp etc. While framshift bp deletion is not in multiples of 3 eg 2bp,4bp etc. In the above question, there are 2bp deletion ie 124bp instead of 126bp. Therefore it is framshift and not codon deletion. Hope this helps.
 

·
Registered
Joined
·
67 Posts
Discussion Starter #4
Codon deletion is deletion of 3 base pairs or bp with in multiples of 3 eg 6bp, 9bp etc. While framshift bp deletion is not in multiples of 3 eg 2bp,4bp etc. In the above question, there are 2bp deletion ie 124bp instead of 126bp. Therefore it is framshift and not codon deletion. Hope this helps.
thanks man
its very helpful
i understand it now because of you
 
1 - 4 of 4 Posts
Top