USMLE Forums banner
1 - 6 of 6 Posts

· Registered
Joined
·
487 Posts
Discussion Starter · #1 ·
A 45-year-old Caucasian male with cough and fever is found on chest x-ray to have a lung infiltrate, hilar adenopathy, and a right-sided pleural effusion. Lung tissue obtained from this patient reveals the findings below.



Which of the following is the most likely cause of this patient's condition?

A. Rhizopus species
B. Aspergillus fumigatus
C. Candida albicans
D. Cryptococcus neoformans
E. Blastomyces dermatitidis
F. Histoplasma capsulatum
G. Coccidioides immitis
H. Sporothrix schenckii
 

· Registered
Joined
·
487 Posts
Discussion Starter · #5 ·
The most correct answer is G) Coccidioides immitis



The image above shows a large spherule filled with small round endospores. Spherules are the tissue form of Coccidioides immitis. This is a dimorphic fungus that exists in the environment in the form of mold (hyphae). It is endemic to the desert areas of the United States and Mexico. Coccidioides can cause lung disease in immunocompetent people and disseminated disease in the immunocompromised.

Microscopic examination of body fluids, sputum, and tissue samples in 10% KOH or silver stain shows thick-walled spherules packed with endospores. Culture on Sabouraud's agar and serology are also important in making the diagnosis.
 
1 - 6 of 6 Posts
This is an older thread, you may not receive a response, and could be reviving an old thread. Please consider creating a new thread.
Top