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Discussion Starter · #1 ·
A 7 y/o boy presents with a low grade fever, arthralgias, colicky abdominal pain, and a palpable purpuric rash limited to the lower extremities. Laboratory studies reveal a guaiac positive stool, a urinalysis with red blood cell casts, hematuria, and mild proteinuria, and a CBC with a normal Hb, Hct and platelet count. Which of the following is the most likely diagnosis?

A. Thrombotic thrombocytopenic purpura
B. Systemic Lupus Erythematosus
C. Poststreptococcal Glomerulonephritis
D. Rocky Mountain Spotted Fever
E. Henoch-Schönlein purpura
F. Hemolytic-uremic syndrome

I want you to think all night and I'll give you the answer by tomorrow... have fun guys

feel :sleepy:
 

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Discussion Starter · #11 ·
E) Henoch-Schonlein purpura

Correct asn is E) Henoch-Schonlein purpura

Henoch-Schonlein purpura is a disease that involves purple spots on the skin, joint pain, gastrointestinal problems, and glomerulonephritis

Henoch-Schonlein is caused by an abnormal response of the immune system. It is unclear why this occurs.

The syndrome is usually seen in children, but it may affect people of any age. It is more common in boys than in girls. Many people with Henoch-Schonlein purpura had an upper respiratory illness in the weeks before.


Henoch-Schönlein purpura (HSP) is a small-vessel vasculitis in which complexes of immunoglobulin A (IgA) and C3 are deposited on arterioles, capillaries, and venules. As with IgA nephropathy serum levels of IgA are high in HSP and there are identical findings on renal biopsy.

Platelet count and coagulation studies: Platelet count is usually in the reference range but may be elevated; the platelet count should not be low in Henoch-Schönlein purpura. A normal platelet count rules out idiopathic thrombocytopenic purpura (ITP). A normal platelet count and normal coagulation studies (ie, PT, aPTT, fibrin split products) rule out thrombotic thrombocytopenic purpura (TTP).

Purple color rash, especially involving the legs
Subcutaneous edema
Abdominal pain and vomiting
Joint pain, especially involving the knees and ankles
Scrotal edema
Bloody stools

Joint Human body Gesture Elbow Trunk

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