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Discussion Starter · #1 ·
NBME FORM 1

which of the following antimicrobial agents most likely to be administered orally for the treatment of potentially serious systemic infections because of its
predictable bio-availability ??

A) Amphotricin B

B) Ciprofloxacin

C) Gentamicin

D) polymexin B

E) Vancomycin
 

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Vancomycin - it has to be given intravenously (IV) for systemic therapy since it does not cross through the intestinal lining. It is a large hydrophilic molecule which partitions poorly across the gastrointestinal mucosa. The only indication for oral vancomycin therapy is in the treatment of pseudomembranous colitis, where it must be given orally to reach the site of infection in the colon.

Amphotricin B - A major barrier to the use of amphotericin in resource-poor settings is that it must be given intravenously (except for topical applications). An oral preparation exists, but is not yet commercially available.

Gentamycin - since their large polarized molecular size, they are not absorbed from the gut, they are administered intravenously and intramuscularly. Some are used in topical preparations for wounds. Oral administration can be used for gut decontamination (e.g., in hepatic encephalopathy)

hope this help you....
 
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