Which enzyme decreased in this woman?

8953 Views 9 Replies 7 Participants Last post by shaan.medico, Jan 24, 2011

aktorque

Discussion Starter · Nov 15, 2010

Q NO 1: A 34-year-old female develops moderate hyperglycemia during her first pregnancy and is diagnosed with gestational diabetes mellitus. Her glycemic status improves markedly after delivery. She says that her mother and younger sister both had “high blood sugars” during pregnancy. If this patient’s gestational hyperglycemia is genetically predisposed, this patient is most likely to have decreased activity in which of the following enzymes?

A. Glucokinase
B. Phosphofructokinase
C. Aldolase
D. Pyruvate kinase
E. Enolase
F. Pyruvate carboxylase
G. Lactate dehydrogenase

?????

Save

Reactions: 1

1 - 3 of 10 Posts

shaan.medico

· #6 · Jan 1, 2011

confusion

yes u r rite..
bt can u plz explain how def in same gene present with three different types??

1) DM type 1
2) MODY
3) hyperinsulinemia and hypoglycemia

???

Save

shaan.medico

· #8 · Jan 2, 2011

u said "it wudnt"

bt i like to make u clear tht i havnt said that it causes these states,
i was saying tht glukokinase gene mutation will "PRESENT AS" these three states, and nw i got the answer, thnx to wikipedia.

DM 1 - when there is homozygous gene mutation resulting in complete absence of gen activity.

MODY 2- when there heterozygous loss in mutation, resulting in decr activity of this gene, resulting in incr. in threshold for this enz.

hyperinsulinemia hypoglycemia- heterozygous gain in mutation, resulting in decr threshold for this enzyme.

btw thnx for replying......

See less See more

Save

shaan.medico

· #10 · Jan 24, 2011

ITS NOT LIKE THE WAY U ARE THINKING,

I m saying that GLUKOKINASE complete loss of function will preent like a state such as DM 1.... its not like glukokinase gene mutation will cause DM1

Save

1 - 3 of 10 Posts

This is an older thread, you may not receive a response, and could be reviving an old thread. Please consider creating a new thread.

Top Contributors this Month