Ok as far as I can relate, the metabolic acidosis doesn't just occur because of loss of bicarbonate in urine, it also occurs because of accumulation of organic acids due to the inhibition of TCA cycle enzymes and alterations in lipid and Amino acid metabolism.Initially there is a respiratory alkalosis due to a direct stimulatory effect on the respiratory centre. To compensate for this there is a loss of bicarbonate from the urine with loss of sodium, potassium and water. This eventually results in a metabolic acidosis, with hypokalaemia and dehydration.
I dont' really get the second mechanism.
Things to keep in mind... metabollic effects of Salicylate poisoning range from Respiratory Alkalosis to Severe Metabolic Acidosis.Why there is Hypokalemia in Salicylate poisoning.................
Ok, so there is resp alkalosis preceding metabolic alkalosis in severe toxicity also? you sure? cuz i'm kind of confused by this! whether there is resp alkalosis preceding met acidosis in SEVERE poisoning.Even in severe toxicity the immediate effect is respiratory alkalosis followed by metabolic acidosis.
2) Inc. loss of potassium from the kidneys due to release of Aldosterone.
(inc loss of potassium & hydrogen in urine)
It is supported by the fact that the pts of severe salicylate poisoning excrete hydrogen & potassium in their urine.
The metabolic respose of salicylate poisoning is dose dependant in high therapeutic dose (moderate toxicity) there is repiratory alkalosis.Ok, so there is resp alkalosis preceding metabolic alkalosis in severe toxicity also? you sure? cuz i'm kind of confused by this! whether there is resp alkalosis preceding met acidosis in SEVERE poisoning.
But the 2nd point made is Excellent, can't believe i forgot about that! haha *thumbs up*