[Guest]

OK am not sure if this is a step 1 (mechanism of disease) or CK question. But I've seen a couple of questions that emphasized the high cholestrol and hyponatremia in hypothyroid patients.
Does anyone know why is that?
I can't seem to understand the relationship

 

[rasheed]

The American Association of clinical endocrinologists states that hypothyroidism is the most common cause of secondary hypercholestrolemia and launched a campaign to educate the public about this issue and that's why it may frequently appear in USMLE questions.

I am not sure what is the exact mechanism but I'd hypothesize that when you have low thyroid activity then your basal metabolic rate and lots of metabolic activities get depressed including those that clear out the body of Cholestrol.

As for the hyponatremia it's not yet understood and some people have talked about an inability to suppress ADH and so it's water retention that's causing the hyponatremia.

 

[FSUSTC]

Thyroid hormone accelerate clearence of cholesterol from the blood , thus hypothyroidism cause hypercholesterolemia ....
Hyponatremia in hypothyroidism is incompletely understood ... its may be due to inability to completely suppress ADH .....

 

[syedaanaqvi]

dont know abt hyponatremia sorry for that.

thyroid hormone effects LDL recepter.

 

[matz]

Good to remember that in hyperlipidemia (due to hypothyroidisim) and hyperproteinemia we have pseudohyponatremia, i dont know if it can be justified or not?!!

 

[neoeinstein]

I was also wondering when I was studying MTBCK Endo section:
I found the answer in MTBCK nepro section

and decreased water excretion leads to Hyponatremia.

 

[LatinGeorge]

Great answers, cleared the concept for me.