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I always thought that if a drug is highly protein bound, it WILL CROSS the placenta?
would it be safe to say that since Phenytoin is teratogenic, one is not left with too much choice for effective treatment of simple and grand mal seizures. Not sure, im just shooting in the dark here.Thx Graymess.
By the way, is there a general rule that says that all lipophilic molecules are protein bounded in the plasma?