Ah, I see - as an adjuvant with concurrent gonadal suppression.Hokolesqua said:It is also used in premenopausal women as well!
as far as i know anastrozole inhibits aromatase -i have not seen any where saying that it does not work inside ovarian granulosa cells -so i would expect it be helpful in premenopausal age as same as post.Anastozole affects extraglandular estrogen production (the source of estrogen in postmenopausal women), rather than ovarian estrogen (the main source in pre-menopausal women), so it would have little effect in a premenopausal woman. Perhaps you might use it in an obese pre- or peri-menopausal pt...:notsure: (correct me if I'm wrong, seniors )
I think that it's not that it doesn't work on the aromatase in the ovaries; rather, that while there is still ovarian estrogen production, there is also still an intact gonadotropin feedback loop to overcome the competition. I'll look into it tomorrow to make sure, and I'll post what I find out here. In the meantime, perhaps someone who knows more than we do will post the answer!as far as i know anastrozole inhibits aromatase -i have not seen any where saying that it does not work inside ovarian granulosa cells -so i would expect it be helpful in premenopausal age as same as post.
please correct me if i am wrong
i my last reply, former= post menopausal; latter=pre menopausal. i am sorry if anyone got confused due to that.:sorry:@dr.ram;"...Estradiol produced in this manner is the cause of tumor growth, more so in post menopausal women than premenopausal women. Thus, anastrozole is more useful in former cases,..."please explain more i do not get this part! why anastrozole is more effective for postmenopause.