USMLE Forums banner
1 - 2 of 2 Posts

·
Registered
Joined
·
4,342 Posts
All males are hemizygous while all females are heterozygous.

There's no homozygous females (because of the random inactivation of one of the X chromosomes).

The inheritance follows one of two patterns:

  1. Both males and females are affected and the typical example is X linked hypophosphotemic rickets.
  2. Manifested only in females and is lethal in utero in males. Examples include incontinenta pigmenti, focal dermal hypoplasia, and orofaciodigital syndrome.
See also
List of X linked recessive disorders
List of Autosomal dominant disorders
 

·
Registered
Joined
·
1,186 Posts
some of the other X-linked dominant disorders examples....

RETT's syndrome (transmitted to both males and females but only females can survive till term..)
charcot marie tooth disease
fragile-X syndrome
alport syndrome( major cases)
 
1 - 2 of 2 Posts
Top