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#1
06-16-2011
 USMLE Forums Guru Steps History: --- Posts: 332 Threads: 48 Thanked 181 Times in 117 Posts
It's the coding strand by default!

Is it true that DNA sequence is given in coding strand in USMLE by convention, unless specified otherwise?
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#2
06-16-2011
 USMLE Forums Guru Steps History: Not yet Posts: 324 Threads: 70 Thanked 246 Times in 146 Posts Reputation: 256

yes it is always given in 5'---->3' direction unless otherwise specified..
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#3
06-16-2011
 USMLE Forums Scout Steps History: Not yet Posts: 40 Threads: 14 Thanked 15 Times in 9 Posts Reputation: 25

Quote:
 Originally Posted by struggle yes it is always given in 5'---->3' direction unless otherwise specified..
I believe the OP is asking about discerning between the coding strand and the template strand, not the polarity of the sequence.
 The above post was thanked by: usluipek (06-16-2011)

#4
06-16-2011
 USMLE Forums Guru Steps History: Not yet Posts: 324 Threads: 70 Thanked 246 Times in 146 Posts Reputation: 256

yes i am saying the same thing that always coding strand is given and when the question doesnt mention whether its a coding strand or template we should always assume it as a coding strand.
 The above post was thanked by: bebix (06-16-2011), Tig2575 (06-16-2011), usluipek (06-16-2011)
#5
06-16-2011
 USMLE Forums Guru Steps History: --- Posts: 332 Threads: 48 Thanked 181 Times in 117 Posts

Hi, thanks to all,

So there are at least two conventions:

Unless specified, DNA sequence
1, is given from 5' to 3'
2, is represented by coding strand instead of template strand.

The 5' - 3' convention is stated in KN, but where is the coding strand stated? Pls provide the official source
 The above post was thanked by: bebix (06-16-2011)
#6
06-16-2011
 USMLE Forums Guru Steps History: --- Posts: 332 Threads: 48 Thanked 181 Times in 117 Posts

Anyone knows where I can find the official statement that DNA sequence is conventionaly given as coding strand?
#7
06-16-2011
 USMLE Forums Guru Steps History: Not yet Posts: 324 Threads: 70 Thanked 246 Times in 146 Posts Reputation: 256

Sorry to say..i dont have any official source to support..but that is what i have heard from everyone..
Regarding 5..>3 direction it was mentioned in the molecular biology video..
Sorry if i misguided u..though my intention was not wrong..:sorry:
#8
06-16-2011
 USMLE Forums Guru Steps History: --- Posts: 332 Threads: 48 Thanked 181 Times in 117 Posts

Struggle, your statement is correct. DNA is conventional given from 5 to 3. You are also correct that coding strand is given unless specified, although two conventions are independent of each other.

Last edited by usluipek; 06-16-2011 at 06:50 PM.
#9
06-17-2011
 Banned Steps History: CK Only Posts: 34 Threads: 6 Thanked 11 Times in 11 Posts Reputation: 13

confused.com

template strand would be in 3' ----> 5' direction correct?

 Tags Molecular-Biology-

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