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-   -   First Aid's Clindamycin mechanism (https://www.usmle-forums.com/usmle-step-1-forum/1192-first-aids-clindamycin-mechanism.html)

lemontea88 01-05-2010 11:26 PM

First Aid's Clindamycin mechanism
 
According to First Aid, clindamycin blocks peptide bond formation.

But when I read Kaplan's pharmaco, it says clindamycin acts just like macrolides, which is to inhibit translocation of peptidyl-tRNA. Only chloramphenicol is involved in disturbing the "peptide bond formation" event in bacterial protein synthesis.

What do you guys think? Does clindamycin act both during the peptide bond formation stage, and also the translocation stage?:confused:

aamand 01-06-2010 08:34 AM

check this article
http://sitemaker.umich.edu/mc3/clindamycin

they mentioned that it works like macrolides on the translocation step of protein synthesis.

fauzan 01-06-2010 08:50 PM

clindamycin acts lyk macrolides on translocation.... acc to katzung review as well.....

rasheed 01-07-2010 05:26 PM

Also have a look here
http://www.usmle-forums.com/usmle-st...sm-action.html


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