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Old 09-09-2011
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Lungs Mystery Shortness of Breath!

A 47-year-old female aerobics instructor is referred to a pulmonologist with a 7 month history of progressive difficulty breathing. The shortness of breath has stopped her from being able to teach over this period of time. Her symptoms only occur during exercise. She has no other medical problems.

She has tried albuterol and corticosteroids without benefit. Chest X-ray is only notable for accentuation of pulmonary vasculature. Which of the following is characteristic of her condition?
A. The mutation leads to proliferation of vascular endothelial lining
B. Increase in vasodilators is implicated in the pathogenesis
C. Right to left cardiac shunts can also be a potential cause
D. Right sided heart failure is a common outcome
E. It is more common in men
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Old 09-09-2011
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D?

Woman, 47 years - something autoimmune...
Albuterol? Corticosteroids? -Asthma? (B2 agonist albuterol)

well I am guessing about right sided heart failure as an outcome of some sort of "problem" in the lungs that would cause constriction and increase resistance...

Right?
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Old 09-09-2011
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A .since it occurs only during exercising.
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Old 09-09-2011
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A. The mutation leads to proliferation of vascular endothelial lining
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Old 09-09-2011
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Quote:
Originally Posted by pass7 View Post
A. The mutation leads to proliferation of vascular endothelial lining
primary pulmonary HTN due to mutation in BMPR2 gene lead to smooth muscle cells hypertrophy not the endothelial cells ??
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Old 09-09-2011
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a) pulmonary hypertension
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Old 09-09-2011
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it's pulmonary hypertension.

a left to right cardiac shunt could be a cause, right? (not a right to left, like in the question)
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Old 09-10-2011
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I think pt. will land to right sided heart failure
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Old 09-10-2011
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its A BMPR mutation ...
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Old 09-11-2011
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D. Right sided heart failure is a common outcome
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it is pulmonary hypertension but right sided heart failure is the outcome
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Old 09-11-2011
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Is the answer A,
idiopathic pulmonary hypertension?
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Old 09-11-2011
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A. The mutation leads to proliferation of vascular endothelial lining
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