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Tsveta 02-13-2010 06:31 PM

Genetics of diabetes
Which is more genetically influenced type I or type II?

I've seen a question telling that type II is more genetic than type I. Then how come we have the HLA association in type I?

Any convincing answer will be appreciated ..

ohmedk 02-14-2010 05:42 PM

Reply to Genetics of Diabetes
It is a commonly seen phenomenon that type 2 diabetes runs in families. That is why we ask for family history for diabetes when we suspect diabetes in a patient. There are multiple genes along with environmental factors involved in this and the exact pattern of inheritance is unknown.

As for type 1 diabetes there is also thought to be a genetic predisposition, but Type 2 diabetes has a stronger genetic basis.

Fun Fact: If you are a woman with type 1 diabetes and your child was born before you were 25, your child's risk is 1 in 25; if your child was born after you turned 25, your child's risk is 1 in 100.

If you have type 2 diabetes, the risk of your child getting diabetes is 1 in 7 if you were diagnosed before age 50 and 1 in 13 if you were diagnosed after age 50.
Source :

Tsveta 02-14-2010 10:01 PM

Thank you ohmedK
but does that mean that HLA typing is associated with Type II not Type I?

Sabio 02-15-2010 03:15 PM

HLA association is only seen in Type I diabetes and not in Type II.
However, the role of genetics is stronger in Type II as you have 20% of patients having first degree relative affected while the percentage is only 10% in the case of Type I.
The most acceptable theory so far about the development of Type I is autoimmune destruction of the islet cells possible triggered by a virus in a genetically susceptible individuals.
While in Type II it's mainly the metabolic syndrome with obesity and insulin resistance that are playing role in the pathogenesis. Some papers indicated a possible autosomal dominant mode of transmission in Type II patients.

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