Died of respiratory disease (lung pathology micrograph)

[m82_ghasemi]

An unmarried, white male, 47 years of age, was admitted to the hospital because of weakness, loss of weight and shortness of breath, especially upon exertion. The temperature was 98.0, pulse 100, respirations 30; Red and white blood cell counts were within normal limits; he weighed 97 pounds (38 pounds below normal). The family and past histories were not informative. He had worked as a plumber in a company in San Antonio for 38 years and before the onset of the present illness 3 months ago. Then he consulted a physician because of annoying cough, weakness, loss of weight and increasing shortness of breath. While in the hospital his general condition improved for a few days more than four months; cough became less irritating, dyspnea less annoying, his appetite improved and he gained eight pounds. Chest x-ray films taken presented a ground-glass appearance with small nodular mottling throughout and fine reticulate markings in the basal portions of both lungs. Assiduous laboratory work failed to demonstrate acid-fast bodies or asbestosis bodies in the sputum. His condition worsened abruptly during the morning; he became dyspneic and cyanotic, the pulse jumped to 116, the respirations rose to 36. He was placed immediately in an oxygen tent and proper medication was administered. After a brief period of apparent improvement his condition gradually became worse and he died 3 days later. At autopsy the body was greatly emaciated, the chest was fiat and the accessory respiratory muscles were prominently hypertrophied. Lung histology with H&E staining is shown below:


click image to enlarge

Which of the following answers is not correct regarding the patient's disease?

A) This disease can lead to diffuse interstitial fibrosis, mainly in lower lobes.
B) Macrophages are responsible for the fibroblastic response in this condition.
C) The disease is a predisposing factor for bronchogenic carcinoma
D) The presence of yellow-brown, rod-shaped bodies with clubbed ends is characteristic finding in histopathology.
E) Cigarette smoking in combination with this condition increases the risk of mesothelioma.
F) Dense hyalinized fibrocalcific plaques of parietal pleura are also present in this disease.
G) The characteristic pulmonary function finding in this disease is a restrictive ventilatory defect.

[Gawtti]

E) Cigarette smoking in combination with this condition increases the risk of mesothelioma.

[akua]

E.not correct regarding dx.

Akua

[doctor KMK]

According to Golijan smoking doesn't predispose to mesothelioma..so i'll go with D

[Poonam aslam]

I ll go withD

[doctor KMK]

Hey I've read the question wrong
answer is E..

[l2sweedan]

C) The disease is a predisposing factor for bronchogenic carcinoma

[moe2185]

E) Im pretty sure this is in FA pretty clear.

[USMLE2011m]

no mesothelioma... so the answer should be E.

[dr.aysa]

E) Cigarette smoking in combination with this condition increases the risk of mesothelioma

[mohitkmc]

E. is the best option here continous exposure to asbestos due to working in industry lead to predisposition to mesothelioma cigarette smoking will worsen his condition bt is not responsible for producing mesothelioma.

[dr.muhamad]

gggggggg
gggg

[ricko335]

i assume it to be a restrictive pathology so i go with g

[USMLE2011m]

Originally Posted by ricko335

i assume it to be a restrictive pathology so i go with g

hey, the question states which one is it NOT most likely to be.

[ricko335]

oops cigarrete smoking to mestohelioma

[Poonam aslam]

Oh it says...not correct....ooops

[Poonam aslam]

I ll go with B then.