USMLE Forums banner

SCID

3K views 1 reply 2 participants last post by  spasemaster 
#1 ·
FA mentions that findings for SCID includes decreased T-cell receptor excision circle (TREC)

I don't understand what TREC is?
 
#2 ·
God bless Wikipedia ;):

T-cell receptor excision circles (TRECs) are small circles of DNA created in T-cells during their passage through the thymus as they rearrange their TCR genes.[1] Their presence indicates maturation of T cells; TRECs are reduced in SCID (Severe combined immunodeficiency disease).
Single joint T-cell receptor excision circles (sjTRECs) were in the news as a way to test the age of the individual from a blood sample.[2] The detection of sjTRECs can be further used as a diagnostic tool to monitor the thymic output e.g. following hematopoietic stem cell transplantation or in case of AIDS [3]
 
This is an older thread, you may not receive a response, and could be reviving an old thread. Please consider creating a new thread.
Top