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  #1  
Old 03-18-2010
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Drug Continuous GnRH

The continuous administration of Gonadotropin-Releasing hormone is most likely to elicit which of the following long term changes in the release of luetinizing and follicle-stimulating hormones?

A- Increase
B- Decrease
C- Loss of cyclicity without a decrease or increase
D- No changes
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Old 03-18-2010
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Quote:
Originally Posted by Yallah View Post
The continuous administration of Gonadotropin-Releasing hormone is most likely to elicit which of the following long term changes in the release of luetinizing and follicle-stimulating hormones?

A- Increase
B- Decrease
C- Loss of cyclicity without a decrease or increase
D- No changes
I think B.Decrease
This inhibits the release of gonadotropins inducing a down-regulation of pituitary GnRH receptors and a state of hypogonadotropic hypogonadism.
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Old 10-30-2010
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b - decrease
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Old 10-30-2010
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I think C- Loss of cyclicity without a decrease or increase
because acutely you would get an increase in LH and FSH, but with long term administration the system would adapt and return to baseline release. However, since you are giving it continuously you would lose cyclicity. I think...

I just realized this is a really old post...can you please post the answer Yallah?
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Old 10-30-2010
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B. But according to memory, there should be an initial increase in FSH/LH and then the decrease?? I think I came across that in UW. Not sure though
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Old 10-31-2010
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i should be B. because continuous is used to treat prostate cancer n works as an antagonist. discontinuous/pulsatile fashion is used to treat infertility. Leuprolide is the drug name.

yes they asked this in UW n kaplan qbank.
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Old 10-31-2010
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Thats what I have - Leuprolide used as a treatment causing an eventual decrease... Do you guys have a reference for the initial increase? I can't seem to remember where in UW I saw it...
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Old 11-01-2010
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Quote:
Originally Posted by ashishkabir View Post
Thats what I have - Leuprolide used as a treatment causing an eventual decrease... Do you guys have a reference for the initial increase? I can't seem to remember where in UW I saw it...
look in FA. initial transient burst of FSH n LH but then decreases n stays that way.
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