Q. prostatic ca, total vs free PSA

[Aumsai]

Q. In prostatic adenocarcinoma, there is increased total PSA, with decrease fraction of free PSA. Can anybody pls explain why decrease fraction of freePSA?Any relation between total and free PSA?(From: FA, prostatic adenocarcinoma under reproductive pathology)

[rooney_hattrick]

Originally Posted by Aumsai

Q. In prostatic adenocarcinoma, there is increased total PSA, with decrease fraction of free PSA. Can anybody pls explain why decrease fraction of freePSA?Any relation between total and free PSA?(From: FA, prostatic adenocarcinoma under reproductive pathology)

In cases of high serum PSA, the fraction of free PSA is inversely proportional to the risk for malignancy i.e. High free PSA fraction: Likely a benign process, Low free PSA fraction: Likely a malignant process. Why? I don't know. Maybe in Ca, there is production of some binder molecules as well. Don't think we should know this for Step 1.

The way I remember:

If you've got a malignant disease, you're BOUND to your bed.
If you've got a benign disease, you're FREE to move around.
(A friend of mine told me this - pretty handy)

[Aumsai]

Thanks Rooney Hatrick. Now, got it.