Coagulation Panel Question - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
USMLE Articles
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam

Thread Tools Search this Thread Display Modes
Old 07-20-2015
USMLE Forums Newbie
Steps History: Not yet
Posts: 1
Threads: 1
Thanked 0 Times in 0 Posts
Reputation: 10
Default Coagulation Panel Question

I am confused about the results from a coagulation panel in a patient diagnosed with DVT due to hypercoagulation caused by factor V leiden.

So PT, INR, aPTT are all normal. D-Dimer is nearly triple the normal value (which is expected).

My question is, why are PT, INR and aPTT not lowered or abnormal? My reasoning is that the hypercoagulation would cause faster rates of clotting.

Any help is appreciated. Thanks
Reply With Quote Quick reply to this message

Old 07-20-2015
USMLE Forums Scout
Steps History: Step 1 Only
Posts: 34
Threads: 6
Thanked 13 Times in 6 Posts
Reputation: 23

would be nice to see the full question,
Factor V leiden mutation causes heriditory thrombosis syndrome, here mutant factor 5 not inactivated by protein c, since it acts at common pathway of intrinsic and extrinsic coagulation pathways i guess coagulation factor levels not affected hence time remains the same but shouldn't it prolong clotting time?

And can u help me differentiating leiden and protein c/s defiency
Reply With Quote Quick reply to this message


Quick Reply

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Please enter a password for your user account. Note that passwords are case-sensitive.
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Where you live. Leave blank if you don't want to tell.


Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes

Similar Threads
Thread Thread Starter Forum Replies Last Post
A question about coagulation pathway Seckinbilgic USMLE Step 2 CK Forum 10 07-07-2014 12:12 AM
Coagulation question philsexy876 USMLE Step 1 Forum 5 04-21-2014 01:59 PM
Coagulation pathway Umesh USMLE Step 1 Forum 1 03-13-2014 10:11 AM
Patient with bleeding and this coag panel scopusmount USMLE Step 1 Forum 4 11-11-2011 03:18 PM
Test your knowledge #19! (Coagulation) Mondoshawan USMLE Step 1 Forum 6 03-18-2011 11:03 AM

Find Us on Facebook
Powered by vBulletin® Version 3.8.8
Copyright ©2000 - 2021, vBulletin Solutions, Inc.
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2021 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2019)