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| USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam |
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#1
09-21-2015
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Methanol poisoning
Methanol poisoning is dangerous because it can metabolize to formic acid. This causes anion-gap acidosis and is toxic.
But this got me thinking: why can't metabolism of ethanol, to acetic acid, cause anion gap acidosis? and why isn't acetic acid toxic? I mean, obviously it's not toxic, since it's ubiquitous in the body. But, why isn't it, from a biochemical perspective? 
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#2
09-22-2015
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Because it is converted to acetyl CoA which enters TCA cycle
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| The above post was thanked by: | ||
Joshua Diamond (09-28-2015) | ||
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#3
09-29-2015
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Quote:
I wrote up this fact, and a lot of other details about methanol toxicity, in this blog post. I hope that you will read it and find it helpful.
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