Please help about dyslipidemia

[bimaindra26]

In a case, there's a patien with metabolic syndrome with total cholestrerol 270mg/dL, LDL 210mg/dL, HDL 38mg/dL. What the best treatment for this patient?
Fibrate? Niacin? Statin?
Need your expleation too
Thanksss

[gokulramani]

Originally Posted by bimaindra26

In a case, there's a patien with metabolic syndrome with total cholestrerol 270mg/dL, LDL 210mg/dL, HDL 38mg/dL. What the best treatment for this patient?
Fibrate? Niacin? Statin?
Need your expleation too
Thanksss

I would say, the single best drug in this scenario would be a statin. It will lower LDL and modestly increase HDL. It can cause myopathy and rhabdomyolysis. So watch out for ant CYP inhibitor interactions(except pravastatin).

Niacin, it's pretty much the best HDL raising agent. But it's not so effective as a mono therapy. It's also notorious for prostaglandin release,causing flushing. So pretreat with aspirin.

Fibrates are good for hyper-triglyceridemia. Modestly lowers LDL. Nothing's mentioned about triglycerides here.