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Old 04-18-2010
Yallah's Avatar
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Default Research Drug Half Life?

A new research drug under study has been found to have a volume of distribution of 35L and a clearance of 690 ml/min. Minute half life of this drug is closest to which of the following values?

A- 15
B- 35
C- 65
D- 105
E- 205
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Old 04-18-2010
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Although USMLE is not very fond of memorizing formulas, the following one may save the day in such questions as the present one.

t1/2 = (0.7 x Vd) / Clearence

690 mL/min = 0.7 L/min approximately.

So, (0.7 x 35L) / 0.7 L/min = 35 min (choice B).
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Old 04-18-2010
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yes that is the ans. 35
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Old 04-19-2010
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yup yup. i agree. B is the answer:

t1/2 = (0.7 x Vd) / CL
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