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  #1  
Old 03-17-2012
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RBC Classify this hemolytic anemia?

A middle age patient presents with history of tiredness, pain in his abdomen, and sexual dysfunction. Blood lab results shows a decrease serum haptoglobin, and a normocytic anemia with pancytopenia. The patient's condition is best described as

A. Intrinsic hemolytic anemia/extravascular hemolysis
B. Extrinisc hemolytic anemia/intravascular hemolysis
C. Intrinsic hemolytic anemia/intravascular hemolysis
D. Extrinisc hemolytic anemia/extravascular hemolysis
E. Positive Direct Coomb's Test/extravascular hemolysis
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  #2  
Old 03-17-2012
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Ans .....C .............
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Old 03-17-2012
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Low haptoglobin... C? anemia of chronic disease?
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Old 03-17-2012
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B..........due to drug or cancer.............but not sure about the agent..........
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Old 03-17-2012
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i would go with option (b) as decreased serum haptoglobin reflecting intravascular haemolysis and pancytopenia with normochromic anemia more likely extrinsic haemolysis
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Old 03-17-2012
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WTF..........Hey when I solved the Qs there was also a sucrose water test in it
which lead me to PNH ....... and C as the ANS ........
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Old 03-17-2012
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....Bunny has the final say...I was in your shoes once or twice, I know the feeling, some alteration was added just right after I had made the decision...Hope that bunny will add more Qs tomorrow...It's your chance of redemption tomorrow hit-everything-man...
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Old 03-17-2012
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Quote:
Originally Posted by patho2012 View Post
....Bunny has the final say...I was in your shoes once or twice, I know the feeling, some alteration was added just right after I had made the decision...Hope that bunny will add more Qs tomorrow...It's your chance of redemption tomorrow hit-everything-man...

, sure ........
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  #9  
Old 08-11-2012
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C is correct,pancytopenia and sexual dysfunction are features of PNH.
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Old 08-11-2012
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decrease serum haptoglobin------> intravascular
normo, pan ----> intrinsic ?>>
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  #11  
Old 08-11-2012
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PNH occur lysis of RBCs, neutroph and platelets due STEM CELL disease, a defect in DAF, the question doesn`t indicate any intake of drug, wich may cause aplastic anemia (cloramph, alkilating agents, methimazole)
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  #12  
Old 08-15-2012
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Quote:
Originally Posted by bunny View Post
A middle age patient presents with history of tiredness, pain in his abdomen, and sexual dysfunction. Blood lab results shows a decrease serum haptoglobin, and a normocytic anemia with pancytopenia. The patient's condition is best described as

A. Intrinsic hemolytic anemia/extravascular hemolysis
B. Extrinisc hemolytic anemia/intravascular hemolysis
C. Intrinsic hemolytic anemia/intravascular hemolysis
D. Extrinisc hemolytic anemia/extravascular hemolysis
E. Positive Direct Coomb's Test/extravascular hemolysis
B is correct answer:

Intravascular hemolysis: hemoglobinemia, hemoglobinuria, hemosiderinuria, methemoglobinemia, decreased haptoglobin and hemopexin; increased LDH

Causes of intravascular hemolysis: activation of complement on erythrocyte, physical of mechanical trauma to the RBC; soluble toxic substances

Extrinsic hemolysis: decreased haptoglobin, increased LDH; increased indirect bilirubin

Causes of extrinsic hemolytic: drugs, toxin, hypersplenism, autoimmunine (cold agglutinin), microangiopathic (DIC, TTP, HUS)
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