what is the effect on thrombin time [ time taken for conversion of fibrinogen to fibrin ] in vitamin K deficiency and why ? - USMLE Forums
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Old 06-07-2012
tyagee's Avatar
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Default what is the effect on thrombin time [ time taken for conversion of fibrinogen to fibrin ] in vitamin K deficiency and why ?

what is the effect on thrombin time [ time taken for conversion of fibrinogen to fibrin ] in vitamin K deficiency and why ?
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Old 05-18-2013
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Default It is increased.

both in dysfibrinogenemias and treatment with heparin.
I just read that much in my UW. With Vit k I think because it agian finally interferes with thrombin formation, i should increase. Correct me if I am wrong.
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Old 05-18-2013
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Quote:
Originally Posted by DrPKR View Post
both in dysfibrinogenemias and treatment with heparin.
I just read that much in my UW. With Vit k I think because it agian finally interferes with thrombin formation, i should increase. Correct me if I am wrong.
It's because activated vit K acts as a cofactor
For gamma carboxylation of factor 2 ,7,9,10,
Protein C & S , activated factor 2 in turn is
Needed for conversion of fibrinogen to fibrin
Monomers. Hope that helps.
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