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sohag100 10-25-2016 08:34 PM

Repeated USMLE Questions Step 1 (75)
 
Workers in the aniline dye industry are more susceptible to bladder cancer than general population. Studies show that animals, when exposed to beta-naphthylamine develop liver cancer but not bladder cancer.
What is the most likely explanation of this finding
A-Metabolism of beta-naphthylamine by human cytochrome 450 system in the liver
B-Detoxification of beta-naphthylamine by glucuronic acid conjugation.
C-Human urinary β-glucuronidase splits beta-nephthylamine into glucuronic acid and a toxic metabolite.
D-Beta-naphthylamine is directly carcinogenic to human bladder
Answer


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