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Old 10-26-2016
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Default Complement deficiency

Suppose a person is born with a congenital deficiency in C2, how will the levels of other complement components be affected?
I expect C1 and C4 (as well as C4a and b) to be normal. C3 levels should be higher since it will not be activated by the classica pathway (only alternative and lectine). C3b should therefore be decreased. I also expect the same for the other components which means that C5, 6, 7, 8 and 9 should increase while the fragments (C5b and C5a) should decrease (but not be equal to zero since the other pathways aren't affected.
What do you think?
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