At his annual physical examination, a 59-year-old man complains of aching in his thighs that occurs during his 5-mile morning runs. He has made no significant changes in the length or speed of the running schedule. The patient has a history of elevated blood lipids and has been taking a standard daily dose of a statin drug for the past 2 years. A routine laboratory profile is normal, but the creatine phosphokinase (CPK) value is elevated. A deficiency in which of the following substances created by the statin drug is causing the patient’s symptoms?
a) Cholesterol
b) Dehydroepiandrosterone
c) Isoprene
d) Vitamin D
I'll go with a. Decre mevalonate decre squareness decre lanosterol decree cholesterol which can lead to decre in vit d, decre steroids and decre isoprene which stabilize cell membrane. Also decre Nile acids
At his annual physical examination, a 59-year-old man complains of aching in his thighs that occurs during his 5-mile morning runs. He has made no significant changes in the length or speed of the running schedule. The patient has a history of elevated blood lipids and has been taking a standard daily dose of a statin drug for the past 2 years. A routine laboratory profile is normal, but the creatine phosphokinase (CPK) value is elevated. A deficiency in which of the following substances created by the statin drug is causing the patient’s symptoms?
The question was asking about the deficiency related to the symptoms/side effects of the statins - elevated CK-MB = muscle destruction. Low level cholesterol is not the cause. Deficiency in Q10 is.
The official explanation:
Ten isoprene units are needed to form the tail on coenzyme Q10. A deficiency in isoprene in the cholesterol pathway would create a coenzyme Q10 deficiency and impair energy metabolism in muscle.
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