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Old 01-24-2017
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Default Question about diuretics!

Hi guys! so i was reading FA and came across this and im getting confused.

ACE inhibitors: inhibit ACE --> decrease Angiotensin 2 --> decrease GFR by preventing constriction of efferent arterioles. Incease in Renin due to loss of negative feedback.


Can someone please explain how is it used in HTN if its increasing renin.
Sorry i feel really dumb right now by asking this question but i feel stuck right now. Really appreciate ur input.
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Old 01-25-2017
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Good question usmle_za,
Renin is an enzyme that converts angiotensinogen into angiotensin 1. Renin by its self does not effect the vascular resistance. Ace inhibitors by inhibiting the production of angiotensin 2, dilate efferent arterioles, hence decreasing glomerular pressure.
Hope that helps
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Old 01-25-2017
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Renin builds up because the blockage occurs further down the road. However, it's not renin we're looking to decrease since it doesn't increase blood pressure, we're looking to decrease both angiotensin II and aldosterone since these exert the greatest effect.
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Old 01-25-2017
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Thanks to both of u... yes the greatest effect is due to the vasodialation by blocking AT 2 and further by decreased production of aldosterone.
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