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-   -   Two Pharmacology Questions? (https://www.usmle-forums.com/usmle-step-1-forum/3402-two-pharmacology-questions.html)

Seetal 07-26-2010 02:01 AM

Two Pharmacology Questions?
 
1. If a drug is highly bound to plasma proteins, it:

a. has a large Vd.
b. has a high renal clearance.
c. is a likely candidate for drug interactions.
d. is most likely carried by alpha-glycoprotein.
e. is a quaternary ammonium salt.

2. most drugs gain entry to cells by:

a. passive diffusion with zero-order kinetics.
b. passive diffusion with first-order kinetics.
c. active transport with zero-order kinetics.
d. active transport with first-order kinetics.
e. passive diffusion through membrane pores.

doc_study 07-26-2010 07:52 AM

I think its

1. C
2. B

khushboo 07-26-2010 08:51 AM

c. is a likely candidate for drug interactions
b. passive diffusion with first-order kinetics.

Kabutar111 07-26-2010 12:39 PM

Vd?
1)i go with c, interaction as it will bound longer and can be displaced by som another drug from its site.
2)lipid soluble m and first order kinetics:sleepy:

Seetal 07-26-2010 04:23 PM

yup yup
 
u guys are ryte.. the answers were C & B.

i realise that they are prolly easy questions for u guys, but by posting some questions that i feel i might forget, i know now, after seeing the answers from others, i will always remember.:)

ps: of course, i'm not talking about memorizing answers merely, but surely, i understand the reasons to the answers.

Vd = volume of distribution.


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