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-   -   cell membrane structure (https://www.usmle-forums.com/usmle-step-1-forum/3492-cell-membrane-structure.html)

khushboo 08-02-2010 09:59 AM

cell membrane structure
 
The extracellular matrix and the cytoskeleton communicate across the cell membrane
through which of the following structures?
A. Proteoglycans
B. Integrins
C. Cadherins
D. Intermediate filaments
E. Microtubules

inder 08-02-2010 09:28 PM

B) integrins???

khushboo 08-03-2010 05:51 AM

yup its integrins...
explanation given by UWORLD...
The integrins are transmembrane heterodimers that act as membrane receptors for extracellular matrix components. The best examples are the fibronectin receptor and the laminin receptor. The receptor structure includes an intracytosolic portion that binds to the actin cytoskeleton through the attachment proteins talin or -actinin. The extracellular portion has specificity for extracellular matrix molecules. The N-cadherins function as transmembrane glycoproteins involved in the formation of parts of the intercellular junctional complexes. Proteoglycans are located on the extracellular surface of the plasma membrane and throughout the extracellular matrix. Cadherins are components of the desmosome and zonula adherens. Microtubules and intermediate filaments are found intracellularly and constitute the cytoskeleton.


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