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USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam |
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#1
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a researcher is going to study regarding HIV infection.He makes a substance X and then he inserts the substance xto the transgenic mice.mice starts producing large amounts of CTLs .the substance he injected particularly acts on.
a)tat gene b)CXCR4 d)POL gene e)nef gene f)CCR5 |
The above post was thanked by: | ||
IMGdoctor (11-10-2012), maverick doc (11-09-2012), subbi (11-08-2012), trupti (11-09-2012), venky2600 (11-08-2012) |
#2
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i think it's E) nef gene........but not that sure...went with it coz nef gene decreases MHC1 expression on infected cells
thanks for the question... ![]() |
#3
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I think CXCR4 since it's found in T cells................
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#4
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normally nef gene decreases expression of MHC 1.so substance x acts on nef gene to decrease its secretion>>>>>increase MHC 1>>>>>increase in CTLS.........
I like this concept .... |
#5
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![]() but i gotta doubt..i really wanna know how substance x decrease nef gene secretion(i mean is it presented in the question..?)............and do really such kinda substance exist..?...pls correct me.. thanks ![]() |
#6
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thanks.... |
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venky2600 (11-09-2012) |
#7
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#8
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a researcher is going to study regarding HIV infection.He makes a substance X and then he inserts the substance xto the transgenic mice.mice shows decresed transcription of all HIV genes.The substance injected particularly acts on: a)tat gene b)CXCR4 d)POL gene e)nef gene f)CCR5 |
#9
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![]() thanks ![]() |
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trupti (11-09-2012) |
#10
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yup!..trans activator of transcription(tat)-mutation /inactivation:reduces transcription of HIV genes.Tat antagonist have been studied for rx of HIV.
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