immuno 2

[rupesh]

a researcher is going to study regarding HIV infection.He makes a substance X and then he inserts the substance xto the transgenic mice.mice starts producing large amounts of CTLs .the substance he injected particularly acts on.
a)tat gene
b)CXCR4
d)POL gene
e)nef gene
f)CCR5

[venky2600]

i think it's E) nef gene........but not that sure...went with it coz nef gene decreases MHC1 expression on infected cells

thanks for the question...

[subbi]

I think CXCR4 since it's found in T cells................

[rupesh]

normally nef gene decreases expression of MHC 1.so substance x acts on nef gene to decrease its secretion>>>>>increase MHC 1>>>>>increase in CTLS.........
I like this concept ....

[venky2600]

Originally Posted by rupesh

normally nef gene decreases expression of MHC 1.so substance x acts on nef gene to decrease its secretion>>>>>increase MHC 1>>>>>increase in CTLS.........
I like this concept ....

thanks for the question...

but i gotta doubt..i really wanna know how substance x decrease nef gene secretion(i mean is it presented in the question..?)............and do really such kinda substance exist..?...pls correct me..

thanks

[rupesh]

Originally Posted by venky2600

thanks for the question...

but i gotta doubt..i really wanna know how substance x decrease nef gene secretion(i mean is it presented in the question..?)............and do really such kinda substance exist..?...pls correct me..

thanks

i just have asked in the last line of the question where actually the drugs works....and rest of the options does not increases CTLS .....so we have to assume that.....
thanks....

[trupti]

Originally Posted by rupesh

normally nef gene decreases expression of MHC 1.so substance x acts on nef gene to decrease its secretion>>>>>increase MHC 1>>>>>increase in CTLS.........
I like this concept ....

VOILA..

[trupti]

Originally Posted by rupesh

a researcher is going to study regarding HIV infection.He makes a substance X and then he inserts the substance xto the transgenic mice.mice starts producing large amounts of CTLs .the substance he injected particularly acts on.??
a)tat gene
b)CXCR4
d)POL gene
e)nef gene
f)CCR5

I will frame the same q in different way,i hope u wont mind,(just to refresh the concepts)
a researcher is going to study regarding HIV infection.He makes a substance X and then he inserts the substance xto the transgenic mice.mice shows decresed transcription of all HIV genes.The substance injected particularly acts on:

a)tat gene
b)CXCR4
d)POL gene
e)nef gene
f)CCR5

[venky2600]

Originally Posted by trupti

I will frame the same q in different way,i hope u wont mind,(just to refresh the concepts)
a researcher is going to study regarding HIV infection.He makes a substance X and then he inserts the substance xto the transgenic mice.mice shows decresed transcription of all HIV genes.The substance injected particularly acts on:

a)tat gene
b)CXCR4
d)POL gene
e)nef gene
f)CCR5

i'll go with A) tat gene...........

thanks

[trupti]

Originally Posted by venky2600

i'll go with A) tat gene...........

thanks

yup!..trans activator of transcription(tat)-mutation /inactivation:reduces transcription of HIV genes.Tat antagonist have been studied for rx of HIV.